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Toll-like receptor 3 Antibodies
AND TLR3 ELISA kits, Toll-like receptor 3 Proteins
Many biological assays use antibodies to detect Toll-like receptor 3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Toll-like receptor 3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Toll-like receptor 3 antibodies...
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TLR3 Infographic by Boster Bio
All TLR3 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$499
Cat # EK0907
96 wells/kit, with removable strips.
Cat # EK0907
96 wells/kit, with removable strips.
Anti-TLR3 Antibody Picoband®
3 Citations 16 Q&As
Human, Mouse, Rat
ELISA, WB
$370
Cat # A00197
100 μg/vial
Cat # A00197
100 μg/vial
Anti-Toll-like receptor 3 TLR3 Antibody
2 Citations
Human, Mouse
ELISA, IF, IHC-P, ICC, WB
$449
Cat # A00197-2
0.1 mg
Cat # A00197-2
0.1 mg
TLR3 Overview
Facts about Toll-like receptor 3.
Toll-like receptor 3 (TLR3)
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through comprehension of molecular patterns unique to germs.
TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, resulting in NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response.
Gene Information
| Human | |
|---|---|
| Gene Name: | TLR3 |
| Uniprot: | O15455 |
| Entrez: | 7098 |
Family
| Belongs to: |
|---|
| Toll-like receptor family |
Alternative Names
CD283 antigen; CD283; TLR3; toll-like receptor 3
Molecular Weight
Mass (kDA):
103.829 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4q35.1 |
| Sequence: | 4; NC_000004.12 (186069156..186088073) |
Tissue Specificity
Expressed at high level in placenta and pancreas. Also detected in CD11c+ immature dendritic cells. Only expressed in dendritic cells and not in other leukocytes, including monocyte precursors. TLR3 is the TLR that is expressed most strongly in the brain, especially in astrocytes, glia, and neurons.
Subcellular Localizations
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome membrane. Early endosome.
Diseases
- Virus Diseases
- Innate Immune Response
- Inflammation
- Infective Disorder
- Malignant Neoplasms
- Neoplasms
- Inflammatory Response
- Autoimmune Reaction
- Hepatitis
- Melanoma
- Influenza
- Autoimmune Diseases
Interacting Proteins
- PIK3R1
Pathways
- Immune Response
- Secretion
- Innate Immune Response
- Cytokine Production
- Pathogenesis
- Inflammatory Response
- Viral Replication
- Cell Activation
- Localization
- Cell Proliferation
- Cell Death
- Rna Interference
- Cytokine Secretion
PTMs
- Phosphorylation
- Methylation
- Cleavage
- Ubiquitination
- Glycosylation
- Phosphorothioation
- Myristoylation
Research Areas
- Cytokine Research
- Immune System Diseases
- Immunology
- Innate Immunity
- Necroptosis
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TLR3
bosterbio.com/bosterbio-gene-info-cards/TLR3
References
PMID: 9435236 by Rock F.L., et al. A family of human receptors structurally related to Drosophila Toll.
PMID: 17085778 by Lafon M., et al. The innate immune facet of brain: human neurons express TLR-3 and sense viral dsRNA.
3 Publications of Boster Toll-like receptor 3 Antibodies & ELISA Kits
- PubMed ID: 10.1089/scd.2019.0039, A Study of the Immunoregulatory Function of TLR3 and TLR4 on Mesenchymal Stem Ce...
- PubMed ID: 33607154, Liao L,Huang L,Wei X,Yin L,Wei X,Li T.Bioinformatic and biochemical studies of f...
- PubMed ID: 33607154, Liao L,Huang L,Wei X,Yin L,Wei X,Li T.Bioinformatic and biochemical studies of f...
*More publications can be found for each product on its corresponding product page